Blar i forfatter "Moens, Ugo Lionel"

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    • High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis 

      Bitossi, Camilla; Viscido, Agnese; Prezioso, Carla; Brazzini, Gabriele; Trancassini, Maria; Borrazzo, Cristian; Passerini, Sara; Frasca, Federica; Scordio, Mirko; Sorrentino, Leonardo; Oliveto, Giuseppe; Fracella, Matteo; D'Auria, Alessandra; Selvaggi, Carla; Cimino, Giuseppe; Midulla, Fabio; Pierangeli, Alessandra; Antonelli, Guido; Moens, Ugo Lionel; Pietropaolo, Valeria; Scagnolari, Carolina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were ...

    • MCPyV Large T antigen induced atonal homolog 1 (ATOH1) is a lineage-dependency oncogene in Merkel cell carcinoma. 

      Fan, Kaiji; Gravemeyer, Jan; Ritter, Cathrin; Rasheed, Kashif; Gambichler, Thilo; Moens, Ugo Lionel; Shuda, Masahiro; Schrama, David; Becker, Jürgen C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-07)
      Despite the fact that the transcription factor ATOH1 is a master regulator of Merkel cell development, its role in Merkel cell carcinoma (MCC) carcinogenesis remains controversial. Here, we provide several lines of evidence that ATOH1 is a lineage-dependent oncogene in MCC. Luciferase assays revealed binding of ATOH1 and subsequent activation to the promoter of miR-375, which is one of the most ...